Sentence examples for binding specificity of ligands from inspiring English sources

Surprisingly, the binding specificity of ligands to the receptors of one subtype is only moderate.

This approach combines the binding specificity of targeting ligands with the selective cytotoxicity of MAP towards proliferating cells.

Together these findings establish the rules for determining the binding specificity of protein ligands to LRP and to other LDLR (low-density lipoprotein receptor) family members.

In defining the prediction model, we needed to identify the PDZ positions that affect binding specificity of every ligand position.

See Additional file 1: Figure S1 for the ligand binding specificity of each PDZ domain family.

Thus, it is critical to understand the molecular driving forces for the ligand binding specificity of galectins.

This splicing event establishes a selectivity filter to restrict the ligand binding specificity of FGFRb and FGFRc isoforms to mesenchymally and epithelially derived fibroblast growth factors (FGFs), respectively [ 5].

The different positions and binding specificities of the viral ligands raise questions of viral evolution, specifically with regard to viral hosts and reservoirs and when the different viruses acquired the different ligands.

Overall, the site-directed modulation of the ligand-binding specificity of (strept avidins towards ligands other than biotin or its derivatives appears to be challenging.

The fragment approach was then used to analyze and understand the binding specificities of the nine ligands.

Substitution of S252W and P253R alter the ligand binding specificities of FGFR2b and FGFR2c, but retain the ligand-dependent activation properties [ 109], whereas K659N causes receptor hyperactivation [ 110].