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VCN retains the integrin binding specificity of both parental molecules it was derived from, but with a different binding affinity profile.
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It contains sequences binding to Src SH3 domain, which is known to possess binding specificities of both class I SH3 domains (motif [R/K]xxPxxP) and class II SH3 domains (motif PxxPx[R/K]).
We found that the DNA-binding specificity of both orthologs and paralogs of p53 was conserved.
Despite the significantly weaker binding of p73CT compared to ΔNp73β to DNA, the DNA-binding specificity of both p73 proteins was identical.
Lambert, N. et al. RNA Bind-n-Seq: quantitative assessment of the sequence and structural binding specificity of RNA binding proteins.
Bu, W. et al. Structural basis for the receptor binding specificity of Norwalk virus.
Kumari, K. et al. Receptor binding specificity of recent human H3N2 influenza viruses.
Kutluay, S. B. et al. Global changes in the RNA binding specificity of HIV-1 Gag regulate virion genesis.
This result further demonstrates the binding specificity of the RBFOX1/2 binding motif and suggests that the SRSF1 motif would not efficiently interact with RBFOX1/2 proteins.
Recent structural and biochemical studies have focused on understanding the glycan receptor binding specificity of the 1957-58 pandemic H2N2 HA.
Xu, H. et al. Collagen binding specificity of the discoidin domain receptors: binding sites on collagens II and III and molecular determinants for collagen IV recognition by DDR1.
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