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The results indicate that although the binding specificity may be guided by molecular shape and H-bond interaction, the charge and hydrophobic interactions contributed most to the binding affinity.
This broad binding specificity may be important for dSfmbt function within the PhoRC complex.
Thus the effect of a change of binding specificity may be that a lost gene is rediscovered.
For instance, the in vivo binding specificity may be similar but not identical to that for naked DNA.
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The selection of a high-percentage of trimer binding specificities may be a consequence our use of trimeric Env antigens during the screening of the EVB-B cell supernatants.
The involvement of residues S338, P378, A430, and Y431 in HBGA-binding specificity may be supported by their common location in a region on one side of the binding interface (Fig. 1C), although the mechanism remains to be elucidated.
However, a SNP that changes DNA-binding specificity may not necessarily be expected to alter protein function.
Accordingly, multifactorial analysis of inhibitor panels and antibody-binding specificities may prove to be a useful technique for weighting the contribution of individual DASH family proteins to DPPIV-mediated degradation of bioactive peptides.
Water molecules in the coenzyme binding interface are also found in many dinucleotide binding domains and may be important for specificity and modulating affinity.
Although the substrate/peptide binding groove may be the key feature for understanding substrate specificity in most kinases, it is and need not be in all.
Affinity of interaction between the PDZ domain and PDZ binding domain may be higher or lower depending on surrounding sequences resulting in the specificity of interaction.
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