Sentence examples for binding specificity in the from inspiring English sources

Consistent with these findings, a designed "humanized" mutant of ecDHFR switches binding specificity in the cell.

Using statistical mechanics, a random-binder model without fitting parameters, with genomic DNA sequence being the only input, we further validate that the nonconsensus nucleotide triplet code constitutes a key signature providing PIC binding specificity in the human genome.

Despite these progresses, little is known about the molecular basis for the altered receptor binding specificity in the evolution of Fujian-like viruses from the A/Panama/2007/99 virus, or the evolutionary relationship between changes in antigenicity and receptor binding specificity.

However, whether such a mutation may alter receptor binding specificity in the pandemic (H1N1) 2009 virus is unknown.

To achieve high binding specificity in the context of a large genome, longer arrays of zinc-fingers are required [ 4].

We observe a similar binding specificity in the interaction of Pellinos with a number of known Pellino substrates.

We also examine a potential global evolutionary mechanism to increase the binding specificity in this type of interaction, and highlight potential cases of cross-talk involving non-native interaction protein pairs.

The resulting differential binding reactivity to all tested toxins suggests that CDR3 alone may play a major role to determine the binding specificity in these two clones.

Each of the aligned overlapping nonamer (9-mer) positions represent a possible antigenic core binding domain for human leukocyte antigen (HLA; human MHC) molecules and T-cell receptors [ 16, 17]; this assumption is based on the fact that there are large array of HLAs with different binding specificities in the human population [ 17].

However, since this prediction matrix is based on NFI binding specificity in vitro, the specificity of this family of proteins may be different from that observed in the cell, where interactions with other transcription factors may take place and DNA accessibility may be restrained by chromatin.

The encoded proteins tested for binding specificity in vitro recognize the same pseudopalindromic sequence with the highest affinity [ 15- 17].