Sentence examples for binding specificity for the from inspiring English sources
As a pair, the central repeat regions of TALENs determine the DNA binding specificity for the two sub-target sites; and the dimeric non-specific FokI cleavage domains cause a DNA double strand break (DSB) between the bound sequences.
The genetically engineered anti-CD20 scFv and GPI-tagged derivative have binding specificity for the CD20 antigen.
In contrast, flexible amino acid residues have rarely been investigated, even though these residues may affect the binding specificity for the cellulose of each biomass.
To overcome these challenges, we have engineered a tetravalent bsAb with bivalent binding specificity for the CD20 and CD3 antigen in an immunoglobulin G (IgG) format.
Using yeast surface display to screen a designed library of Bcl-xL variants, we successfully identified a protein with ~ 1000-fold improvement in binding specificity for the BH3 region of Bad over the BH3 region of Bim.
The resulting Gal4-VP16 fusion protein retains the Gal4's DNA binding specificity for the UAS but is a vastly more efficient transcription factor.
Our resulting binding specificities for the multi-mutant test PDZ domains together with their gold-standard binding profiles withheld during the competition, are shown in Figure 2.
Sequence logos showing primary and secondary binding specificities for the indicated Drosophila (red typeface) and human (gray typeface) transcription factors are shown.
As antibodies recognise their cognate antigens with exquisite selectivity, intense research efforts are devoted to the exploitation of these binding specificities for the development of superior therapeutic agents (Carter, 2006).
Each ApiAP2 protein contains between one and four copies of the signature 60 amino acid AP2 DNA binding domain, and, collectively, several studies have characterized the DNA binding specificities for the P. falciparum ApiAP2 family members (Campbell et al., 2010; De Silva et al., 2008; Flueck et al., 2010; Lindner et al., 2010; Llinás et al., 2008).
