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Binding of the CBD differed between chitin on Au versus chitin on PS in terms of binding strength and binding specificity due to a less homogenous structured chitin-surface on Au in comparison to chitin on PS, despite a similar thickness of both chitin layers in air and after running buffer over the surfaces.
However, current global influenza surveillance does not monitor HA binding specificity due to a lack of rapid and reliable assays.
Similar(58)
The importance of the strength of individual SIMs, as well as of their location and spacing, demonstrated in the present study suggests that other SUMO-binding proteins and STUbLs will display distinct binding specificities due to differences in these parameters.
Although changes in target specificity due to binding with cofactors has not been demonstrated for Sox proteins in Drosophila, it is a well-characterized phenomenon for the Hox family of TFs [ 11, 110, 111].
We questioned whether replacement of crRNA with the predominantly DNA coded crHyb would lead to similar increased specificity due to the reduced binding energy of a DNA DNA duplex destabilising the complex13.
On the other hand, a residue that is far away from the ligand can also affect specificity due to secondary effects on the binding site [ 13, 15].
Upon intravenous injection, virus capsids with optimized in vivo binding behavior may have been enriched in the lung irrespective of tissue specificity due to the first-pass effect after intravenous injection.
(a) Linear relations govern reduction of Cas9 specificity due to genome variations.
BORIS can interfere with CTCF functions in cancer cells not just by virtue of having the identical ZF binding domain and overlapping DNA binding specificity, but also due to its distinct amino- and carboxy-termini that likely confer a discrete set of molecular functions [2].
Protein chaperones, for example, which play a major role in stress response, have low-specificity binding properties due to the large variety of partners they bind to assist conformational search towards global energy minima [ 37, 38].
This is firstly due to the paucity of information about TF binding specificity, confined to a set of loose consensus binding motifs.
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