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By contrast, MPNm2-BSH, which has no DNA binding specificity, did not increase flower initiation in mp-S319 mutant plants.
Similar(59)
Although primarily known for their interaction with the 3' poly(A) tails of mRNAs, in many cases their binding specificity does not distinguish unambiguously between poly(A) and poly dA).
A second hypothesis is that CtrA's DNA-binding specificity did not change in wBm, and only the number of CtrA binding sites reduced.
The possibility to generate such a vast variety of binding specificities does not make obvious sense in the context of vegetative incompatibility especially considering that in N. crassa, incompatibility alleles are very stable, in finite number (two or three alleles) and evolutionarily very ancient.
However, our data also suggest that this RNA-binding specificity does not fully explain the silencing function of Xist A-repeat.
Second, improved specificity did not lower sensitivity.
Specificity did not change.
In all cases where sufficiently high quality data existed for detection of weaker binding sites in both species, the secondary modes were conserved, indicating that TF specificity does not commonly evolve by loss or gain of secondary binding modes.
"Some of you may be thinking that this specificity doesn't make a difference," she wrote.
But increased specificity doesn't bar the possibility of getting our signals crossed.
(33) Reflective of these differences in binding specificities, nisin did not detectably associate with dormant spores (Supplementary Figure S5B), indicating that lipid II was not accessible prior to germination initiation.
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