Sentence examples for binding specificity as it from inspiring English sources
The model demonstrates how the extended and hydrophobic β4 β5 loop of FGF18 is important for conferring FGFR binding specificity as it engages the hydrophobic groove in the D3 domain of FGFR c-isoforms.
However, non-specific binding residues can help specific binding residues to increase binding specificity as well.
Similarly, the BNAR chimera displayed the same binding specificity as Roc1b: it bound Cul3 but not Cul1 (Fig. 2B).
The lower activity of the kdr ZFP2 zinc finger array in the B2H system may be due to low DNA-binding specificity as well as to the lower stringency of the bacterial one-hybrid (B1H) system used to select the kdr-targeted zinc finger arrays (see Discussion below).
The extracellular domains of these receptor proteins are involved in ligand-binding specificity as well as pathogen recognition interactions.
Three residues (27, 54 and 89) from our predictions (red colored in Figure 9) contribute to substrate-binding specificity, as have been noted before in the structural studies of the UMP kinases [ 38]. Figure 9 highlights our predicted functional residues on the adenylyl kinase protein structure.
While the recognition profile of SusD-213 (Fig. 4) is indicating subtle differences in its binding specificity as compared to the antibodies, it is somewhat closer to the binding profile of LM24.
Further, when evaluating binding specificity as a function of affinity it is assumed that complex thermodynamic stability (and relatedly, life time) must be maximized.
Although SC142 scFv originated from the SC142 antibody and demonstrated the same binding specificity as the SC142 antibody, its binding affinity could nonetheless differ from that of the SC142 antibody.
These have broad binding specificity as they bind IGF-1, IGF-2, and also insulin [ 119].
Since the ANBR protein displays the same binding specificity as Roc1a, we wanted to determine whether it could rescue the lethality caused by the null Roc1aG1 mutation [24].
