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Both receptor binding specificity and virus infectivity are key factors in determining whether influenza A virus becomes pandemic.
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Characterization of binding specificity and identification of a novel PDZ domain-containing numb binding protein, LNX.
We next examined the binding specificity and affinity of p62 to type-1 and type-2 residues.
To further identified the relative binding specificities and binding regions, the two rhAbs previously shown to bind to AH/1/05 whole virus in ELISA were tested by IFA with MDCK cells infected with H5N1, H3N2, or H1N1 virus (Figure 1A), or SF-9 cells expressing rHA, rHA1 or rHA2 of AH/1/05 virus (Figure 1B).
Even minor changes in the hemagglutinin molecule may affect receptor binding specificity of the virus, and a single point mutation in the neuraminidase may render the virus resistant to oseltamivir.
Thus, efficient virus replication requires the balanced actions of HA receptor-binding specificity and NA sialidase activity.
Smith, N. C. & Matthews, J. M. Mechanisms of DNA-binding specificity and functional gene regulation by transcription factors.
Bu, W. et al. Structural basis for the receptor binding specificity of Norwalk virus.
In addition, certain amino acid substitutions in HA can switch the binding specificity of a virus from SAα-2,3Gal to SAα-2,6Gal, which can affect organ tropism and even enable transmission between ferrets.
Capsid proteins define cellular receptor specificity and virus antigenicity.
We investigated binding specificity of the mosaic virus and the possible interference of the two fibers during virus life cycle.
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