Sentence examples for binding specificity and stability from inspiring English sources
HOX proteins bind to DNA through a highly conserved 60 amino acid sequence called the homeodomain, and greater DNA binding specificity and stability are achieved when it forms complexes with cofactors such as PBX and MEIS in humans.
Additional binding specificity and stability is in part achieved through interaction with other homeodomain-containing proteins from the multimember PBX or MEIS1 families [17] and co-transduction of MEIS1 with Hox and NUP98-Hox genes also strongly accelerate the onset of leukemia in mice [18] [20].
The optimized construct was a scFv with 13 mutations introduced at key positions in the structure, which retained stability, binding specificity and affinity of the parent antibody.
Its small molecular weight, high stability, high binding specificity, and affinity make it an excellent probe for tumor-targeted imaging in vivo [ 31, 32].
Characterization of binding specificity and identification of a novel PDZ domain-containing numb binding protein, LNX.
We next examined the binding specificity and affinity of p62 to type-1 and type-2 residues.
In vitro binding and specificity were assessed for 125I-Fab, and binding, specificity and internalization were assessed for 111In-Fab using both H314 and A431 cells.
The 68Ga- and 177Lu-labelled ligands were further investigated for lipophilicity, binding specificity, metabolic stability, as well as biodistribution and μPET in LNCaP-tumour-bearing mice.
Though physicochemical nature of the binding sites determine the specificity and stability of the complexes, learning from this manuscript provides a new dimension to protein-RNA recognition based on the type of the organism.
Smith, N. C. & Matthews, J. M. Mechanisms of DNA-binding specificity and functional gene regulation by transcription factors.
The efficiency of evolving new binding function and the size, affinity, specificity, and stability of evolved domains render Gp2 a uniquely effective ligand scaffold.
