Sentence examples for binding specificity and affinity from inspiring English sources
It has been shown that Pbx family members, and their Drosophila melanogaster counterpart Extradenticle (Exd), function as cofactors for Hox proteins; they can enhance their binding specificity and affinity for specific target sequences in DNA [6] [10].
In this regard, Tsh displays similarity to two well-characterized Hox cofactors Extradenticle (Exd) and Homothorax (Hth); homeodomain proteins that bind to Hox proteins altering their DNA binding specificity and affinity (Chan and Mann, 1996; Chan et al., 1996; Mann and Chan, 1996; Ryoo and Mann, 1999; Ryoo et al., 1999).
It is likely, however, that HiR7.8 will bind to androgen-dependent prostate cancer tissue from patients based on binding specificity and affinity similar to previously-identified molecules [ 58].
Isolated scFv were assessed for binding specificity and affinity and may provide the basis for the development of novel immunotherapeutic strategies.
Such 'β-strand addition' contacts can dictate or modulate binding specificity and affinity, or can be used in more promiscuous protein protein contacts.
The protein corona is a dynamic and complex structure whose composition is dictated by the biological medium and the physico-chemical properties of NMs (such as their size, composition, hydrophobicity and charge) as this influences protein binding specificity and affinity.
Therefore, these scDR1αβ molecules will provide a powerful technology platform for further design of DR1 molecules with improved peptide-binding specificity and affinity for therapeutic and diagnostic applications.
Although wt bZIP still targets AP-1 with strongest affinity, both DNA-binding specificity and affinity are maintained with wt bZIP binding to noncognate gene regulatory sequences: the dissociation constant for wt bZIP in complex with AP-1 is 13 nM, while that for C/EBP is 120 nM, XRE1 240 nM, and E-box and HRE are in the μM range.
Structure-based mutagenesis on RolR was carried out and the results confirmed the critical roles of the above mentioned residues for effector-binding specificity and affinity.
The cooperative binding of multiple RBDs that recognize similar sequences allows realizing a wide range of binding specificities and affinities to different mRNAs.
The bacterial production of functional antibody fragments and their efficient display on a filamentous phage particles have made it possible to construct large and diverse combinatorial antibody phage display libraries for the isolation and evolution of antibodies with an enormous diversity in binding specificities and affinities [ 32].
