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As a consequence, even very rare binding specificities present in large repertoires can be selected and amplified from a background of phages with irrelevant binding specificities.
Despite significant number of differences in the number of TFs, most binding specificities present in mammals were also identified in Drosophila, suggesting that the gene regulatory code is highly conserved.
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Additionally, our results indicated that CF172 did not inhibit the CXCL8-mediated signaling of human CXCR2 (Fig. 2b), which was consistent with the observed binding specificity presented in Figure 1.
The results of in vitro binding specificity test are presented in Fig. 3.
Representing transcription factor binding specificities in this form means that no data is stored on the interaction of binding specificity between different base positions in the binding sites.
The importance of the strength of individual SIMs, as well as of their location and spacing, demonstrated in the present study suggests that other SUMO-binding proteins and STUbLs will display distinct binding specificities due to differences in these parameters.
Despite the fact that the present mAb was derived from healthy human donors, several mouse mAbs with similar, but not identical, binding specificities were previously available in literature.
We have presented a method for predicting PDZ domain binding specificity, used in the DREAM4 peptide recognition domain challenge to determine ligand binding profiles of five multi-mutant ERBB2IP-1 Pdomainsins.
Consistent with these findings, a designed "humanized" mutant of ecDHFR switches binding specificity in the cell.
These findings provide new structural insights into the pH-dependent substrate binding specificity in BGs.
Both radiotracers showed high brain uptake and σ2 receptor binding specificity in mice.
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