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A contemporary review of adsorption chromatography must embrace aspects of fixed-bed, batch suspension and fluidised-bed contacting of complex feedstocks with adsorbents chemically derivatised with ligands with binding specificities for target bioproducts.
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Antibodies are macromolecules with high binding specificity for target antigens.
However, there are several disadvantages to the use of ZFNs, including their expense and the need for extensive screening in order to optimize binding specificity for each target sequence of interest (reviewed by Davis and Stokoe, 2010).
Appropriate tracers have a great binding specificity for molecular targets, upregulated under specific pathologic settings, permitting comparison to the physiological state.
Transcriptome profiling of 55 overexpression strains with reduced fitness identified putative target genes and binding specificities for most known and several uncharacterized transcription factors (Chua et al. 2006).
We obtained binding specificities for 112 DNA-binding proteins representing 19 distinct structural classes.
Although most substitutions will likely disrupt binding specificity for the current target site, a few may create new interaction sites leading to the emergence of novel functions.
We used the computational protein design approach to modify CaM binding specificity for these two targets.
As a pair, the central repeat regions of TALENs determine the DNA binding specificity for the two sub-target sites; and the dimeric non-specific FokI cleavage domains cause a DNA double strand break (DSB) between the bound sequences.
Whaley, S. et al. A. M. Selection of peptides with semiconductor binding specificity for directed nanocrystal assembly.
Predict DNA-binding specificities for Cys2His2 zinc finger proteins.
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