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Activities of these ligands vary according to their binding specificities for different PPARs, and on distributions of these ligands in different organs [ 17].
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We, therefore, asked whether oligomerization of p62 influences the binding specificity for different ubiquitin chains.
In vitro binding experiments have been carried out to classify these κB sites according to their binding specificity for different NF-κB dimers.
LecChip™ lectin microarray chips consisting of 45 selected lectins (Supplementary information, Table S1) that exhibit binding specificities for a variety of different oligosaccharide structures were incubated with 100 μl of the chip-ready samples at 4 °C for 16 h.
Although SP-A and SP-D are very similar in terms of structures and functions [ 7, 8], they have different binding specificities for phospholipids or glycolipids.
Future studies will determine if these motifs, as well as the general allelic polymorphism of NILT genes seen in a single individual may contribute to different binding specificities for an as yet unknown ligand.
It led to divergent fates of internalization for the dopamine D1 receptor [25], various binding specificities for gonadotropin-releasing hormone receptors, and different levels of activation of G proteins for the β2-adrenergic [26], mu-opioid [27], dopamine D2 [28], and human 5-HT2A [29] receptors.
Relatively little is known about signaling and binding specificities of different Wnt and Frizzled proteins.
There is some overlap between the binding specificities of different ETS-family proteins [ 20].
We obtained binding specificities for 112 DNA-binding proteins representing 19 distinct structural classes.
These particular loops possibly play a role in differentiation of substrate-binding specificity for the different subclades and thus bring their broad functional divergence.
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