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Indeed, the presence of TTK binding sites would result in early inactivation in the presence of maternally expressed Ttk.
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A recent theoretical study of lactate dehydrogenase concluded that the V136A substitution at the nicotinamide binding site would result in dramatic changes in catalysis due to effects on PPV, but most studies of temperature-dependent isotope effects focus on equilibrium motions and differences in DADs.
In light of this, spontaneous deamination of the methylated CpG in a canonical Myc-binding site would result in the creation of a noncanonical-binding site, which is desensitized to methylation.
The binding sites would not only reveal mRNA targets but would show GQ motif consensus if that's really the in vivo binding site for Aven.
Our results suggest that the absence of the SP1 DNA binding site would impair or reduce the transcription activity of the SPP1 promoter.
A protein binding site would be an attractive hypothesis.
A defined consensus sequence for the AtoC binding site would greatly facilitate the identification of potential AtoC binding elements.
Having shown that AhR and Arnt depletion enhanced CXCL8 and CCL5 responses, we next explored whether blocking the PAH-binding site of AhR would result in similar effects.
Since a typical 100 μm crystal contains an estimated 10 unit cells, full occupancy of each binding site within the crystal would result in the incorporation of the same number of periodically repeating components within the crystal.
Using the same amplifying strategy as before the H2-binding site would also be present offering a second binding site.
Based on Lin and Riggs (1975), to compensate for dilution of functional, noncoding DNA, a corresponding increase in regulatory protein in the nucleus would be required in order to fully occupy functional TF binding sites, simultaneously resulting in many more nonfunctional sites.
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