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A more realistic description for EF-hand Ca2+ binding sites would involve the incorporation of the influence of both Ca2+ binding sites on each other within the CaM globular domains as schematically illustrated on Figure 5 (Model 3 in Materials and Methods).
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A transcriptional regulatory process that involves either antiparallel binding of two copies of a transcription factor, or binding of a homodimeric factor with antiparallel binding sites, would require an inverted repeat-binding site.
The binding of Sam68 to its two binding sites would be necessary for efficient complex formation, involving the recruitment of U2AF, and so could determine the overall level of v5 exon inclusion.
The binding sites would not only reveal mRNA targets but would show GQ motif consensus if that's really the in vivo binding site for Aven.
A protein binding site would be an attractive hypothesis.
Using the same amplifying strategy as before the H2-binding site would also be present offering a second binding site.
These two binding sites are involved in adipocyte differentiation [ 24].
Further, studies demonstrated that the Cu2+ binding site can involve Asp1 or Glu11.
Unfortunately, this would involve binding O'Donnell's arms and legs and throwing her into a river.
The least costly alternative would involve 1,136 broadcast sites and fewer than 56 other sites.
Regions that display differentiation-dependent changes in hypersensitivity were used to predict binding sites for proteins involved in adipogenesis.
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