Thus, when co-localized, both factors may access the DNA with higher affinity than their individual binding sites alone would allow.
One possibility is that the competitive action of Homer1a on Homer c-c binding sites would isolate mGluR1a from the multiprotein Shank3 complex, thus allowing lateral translocation of the receptor towards the PSD.
However, if the multiple aa-binding sites were organized one by one as shown in Figure 1a, apparently only a few aa-binding sites would be allowed, also due to the stereochemical limitation concerning over-distortion of the RNA's backbone.
The binding sites would not only reveal mRNA targets but would show GQ motif consensus if that's really the in vivo binding site for Aven.
A protein binding site would be an attractive hypothesis.
A defined consensus sequence for the AtoC binding site would greatly facilitate the identification of potential AtoC binding elements.
Using the same amplifying strategy as before the H2-binding site would also be present offering a second binding site.
In the scene of the DRT mechanism, any specific peptide would cost a large source for the replication of the corresponding DRT (even if in the compact form) an aa-binding site would consist of quite a number of nucleotide residues (~15 nt, referring to the structure of a simplest aa-aptamer), and there would be additional spacer sequences to allow the folding.
In the center of the c-Ets-2 binding site, the A(+399 G polymorphism would allow for an enhanced transcription rate in the HAB-specific but not the LAB-specific DNA sequence.
Interesting next steps would be, e.g., the addition of binding sites to the PNIPAM shell that would allow for controlled capture, magneto-thermal aggregation, extraction and release of specifically bound biomolecules in integrated systems, as well as enhanced targeted magnetic resonance imaging and therapy utilizing the stronger response of induced particle aggregates.
