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First, the presence of extended binding sites within a single CRD can enhance interaction with branched glycans, resulting in increases of fivefold to 20-fold in affinity.
To be able to distinguish γ binding sites within a random DNA of some length G, those sites must have an Rfrequency = -log2(γ/G) bits of information to be identified [24].
Finally, to search for transcription factor binding sites within a particular TIMELESS gene that was differentially associated with both genders for depression and sleep-related problems, we implemented the tool ConSite, a platform-independent web resource [83].
Traditionally, this concept has been applied to transcription factor binding sites within a gene regulatory region.
Several web-based tools for identifying potential ZFN binding sites within a given DNA sequence are currently available.
Determining the occurrence and location of active and binding sites within a structure helps achieve this goal.
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3 The coordinates of all putative promoters and/or transcription factor binding sites within an IgR are presented.
However, defining all functional binding sites within an identified promoter is difficult, and the existence of some additional binding sites should be assumed [ 2].
A proposed mechanism to ensure a high fidelity of transcriptional output is functional redundancy between closely spaced binding sites within an enhancer.
By doing this extensive modeling study they have developed the first three dimensional visualization of an anesthetic binding site within a clinically relevant protein.
A single E2F binding site within a 100-bp enhancer is necessary and sufficient to direct the correct spatiotemporal program of G1-S-regulated PCNA expression during development.
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