Sentence examples for binding sites with weak from inspiring English sources
We note that the absence of a strong motif occurrence does not definitively classify peaks as false positives, as some such peaks could represent true binding sites with weak or non-canonical binding motifs.
It is therefore uncertain how conservation methods perform with respect to sensitivity, though it has been suggested that they are more sensitive than PWM scanning at detecting binding sites with weak affinity for the TF [14].
There is precedent for calcium binding to some of the mutated binding sites with weaker affinity.
Another set of binding site with a weaker affinity was described on the surface of the monomer; the fitting equation highlighted that 24 mol of palmitate would bind to 1 mol of β-lg.
Specifically, we studied the overlap of CTCF binding sites with 6 types of genomic annotations, including active promoters, weak promoters, poised promoters, strong enhancers, poised enhancers, and insulators [ 29].
We found a strong association of the p65 binding sites with enhancers linked to GC16 (P <0.0001) and GC19 (P <0.0001), but a weak association with GC15-linked enhancers (P 0.32).
A comparison of the CoA bound binding sites with the statin bound binding sites showed rearrangements.
Approaches including also 'weaker' putative binding sites with very low ChIP-seq coverage did however so far not provide evidence for binding sites diverging significantly from the GAS motif [3], [12].
The conserved DLG motif in the Neh2 region of Nrf2 was identified as a second independent binding site with 100-fold weaker affinity for Keap1 [24].
Together with our analyses of the axin allosteric binding site (24, 51), we hypothesize that GSK-3β, as most (if not all) dynamic proteins (58), has few allosteric binding sites, where weak transient bindings can promote activity.
Various strategies have been developed for drug molecules with strong coordination binding sites, weak coordination binding sites and no coordination binding sites.
