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Whilst all the homology-modelled sheep antibodies possess pocket-like binding sites with various shapes and sizes (Fig. 2), the development of more compact binding pockets has been attributed to closure of the VL-VH interface of the anti-hapten antibodies and improved binding sensitivities [ 28].
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Thus all genes with specificity 3 bind to all binding sites with a specificity 3, possibly connecting multiple source genes with various target genes.
A molecular-mechanics potential is used to reconstruct the coordinates of various binding sites with an average root-mean-square error of 0.61 Å and to reproduce known ligand-induced side-chain conformational shifts.
A comparison of the CoA bound binding sites with the statin bound binding sites showed rearrangements.
19– 21 Root-mean-square deviation RMSD -based clustering of the Mdeviation RMSD -basedormed to clusteringe cofformathens of the binding site with those seen before in various crystal structures.
Recent evidence has shown that impaired miRNA expression or single nucleotide polymorphisms (SNPs) that reside on miRNAs and/or miRNA-binding sites correlate with various human cancers [ 2].
Corresponding regions showed: (1) a greater abundance of polymorphic elements (mostly short interspersed element retrotransposons), and (2) significant enrichment for the motifs of binding sites for various transcription factors, with binding sites for the chromatin-organizing CCCTC-binding factor showing the greatest levels of enrichment in polymorphic short interspersed elements.
Ryanodine receptors (RyRs) are calcium release channels mainly located on the endo(sarco plasmic reticulum, with a majority of their mass (consisting of the regulatory domain with multiple binding sites for various ligands) found in the cytosol, whilst the relatively small transmembrane region forms a cation selective ion channel (Samso et al., 2005).
We designed a series of DNA aptamer sequences specific to doxorubicin, displaying multiple binding sites and various binding affinities.
The promoter region has binding sites for various factors such as SP1 and p300.
Potential drug binding sites on various polymerases have also been reported.
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