Sentence examples for binding sites with five-fold from inspiring English sources

Such a mode of regulation has been proposed for messages of C. elegans MAP Kinase 1 (mpk-1) mRNA, which bears two distinct FBF binding sites with five-fold different binding affinities [33].

Using a stringent fold change threshold, we identified 3,353 and 2,147 binding sites with at least four-fold increased or decreased U2AF65 binding upon HNRNPC knockdown, respectively.

We found overlapping hnRNP-C-binding sites for 1,698 (51%), 90 (4.2%) and 8,004 (7.2%) of U2AF65 binding sites with at least four-fold increased or decreased or unchanged U2AF65 occupancy in the HNRNPC knockdown.

The conserved DLG motif in the Neh2 region of Nrf2 was identified as a second independent binding site with 100-fold weaker affinity for Keap1 [24].

Considering the reports that some evident cleavage signals out of the canonical regions (10th to 11th nt of the regulating sRNAs) were observed [ 22- 25], the binding sites with prominent cleavage signals resided within 8th to 12th nt of the regulating sRNAs were retained.

Here, we present a binding sites database (SitesBase) that given a known protein-ligand binding site allows rapid retrieval of other binding sites with similar structure independent of overall sequence or fold similarity.

A comparison of the CoA bound binding sites with the statin bound binding sites showed rearrangements.

Since with the GBD there is only one Cdc42 binding site in N-WASP, the five-fold excess represents a full saturation of the system.

We simulated a genome of size S G, with N sites binding sites of average fold enrichment f, using N reads mapped sequence reads.

In Panc1 cells, the construct containing all three putative CREB binding sites was 4.2-fold more active with wild-type CREB than inactive mutant CREB.

The remaining two did not have AREs, but instead consisted of a FoxA1-binding site with either TTGCTT (4.6-fold) or the TTGGCAAATA (11.3-fold) motifs (Figure 4C).