Sentence examples for binding sites will have from inspiring English sources

However, a protein with n binding sites will have 2 n possible states, which results in a combinatorial explosion of entities and reactions (Hlavacek et al. 2003, Blinov et al. 2004).

If we hypothesize that under physiological conditions all of the nucleotide binding sites will have either ATP or ADP bound, and that each PII trimer will be bound by at least one molecule of α-ketoglutarate, then the maximum number of different signaling forms of PII would be reduced to 16.

For a genome of a given size, a binding site will have to be much more conspicuous if it is alone than if it is one of many.

A definite assignment of ISRIB's binding site will have to await the structural determination of ISRIB-bound (eIF2B 2 or genetic analyses in which loss-of-function mutations are suppressed by compensating changes in ISRIB analogs.

ClusPro also uses the FFT-based rigid docking with an addition of low energy results clustering under the assumption that a native binding site will have a wide free-energy attractor with the largest number of results [ 81].

Sometimes lyrics sites will have viruses.

Similarly, a more detailed consideration would include binding of the TF to other spurious sites in the genome with large sequence similarity; again we expect such consideration will change the value of Δ G *, but not change the scaling relation r * ∝ ℓ, as longer binding sites will always have a larger maximum affinity.

In addition, even a slight structural change around the binding site will sometimes have a large effect on the docking scores (DeWeese-Scott and Moult 2004; Oshiro et al 2004).

Increasing evidence has suggested that bispecific and multivalent antibodies which have more antigen binding sites will improve their immunogenicity.

Until we have this experimental data, mathematical models of binding sites will help us predict TFBSs and in turn help us infer regulatory effects.

The basic question is whether a library has reached the asymptotic saturation point beyond which no new binding sites will be discovered.