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10.1186/s13072-015-0043-3 VPA-inducexpressionxpression with binding sites which overlap VPA-induced DHSS.
At Pu-bd, the FKH domain dimers contact in trans two different cognate Foxp3 binding sites which overlap.
This new list also includes predicted binding sites which overlap with the TFBSs earlier verified by DNase I footprinting, thus allowing to assess their contribution to the model.
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Analysis of the PPARγ promoter identified a putative Egr-1-binding site, which overlaps with a Sp1-binding site, between nucleotide-184 and -173 relative to the transcription start site.
Equally, MV-H engages its CD46 and SLAM entry receptors at overlapping binding sites which lie along the outside of the β-propeller, whereas HNV-G binds to ephrinB2 and ephrinB3 at the top and centre of the β-propeller.
Cocaine is a transport inhibitor: it docks to the outward facing conformation of the transporter at a site, which overlaps with the substrate binding site.
Of these, the most obvious target for signalling through the ERK pathway is an Ets site, which overlaps with a potential binding site for NF-κB.
A significant portion of the genomic binding regions of these TFs contain more than one binding sites, which explains why the forward tag stacks overlap with the reverse tag stacks.
But note that most of the non-genic islands overlap with transcription factor binding sites, which are, however, less constrained than genic regions [ 41].
Sum1 binds a DNA binding site which resembles, and partly overlaps, the binding site of Ndt80 [ 23], [ 18].
A high-quality nuclear magnetic resonance solution structure of the J-domain of DNAJA1 combined with a bioinformatics analysis and a ligand affinity screen identifies a potential DnaK binding site, which is also predicted to overlap with an inhibitory binding site, suggesting DNAJA1 activity is highly regulated.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com