Sentence examples for binding sites which open from inspiring English sources

Sensing mechanisms potentially include cryptic binding sites which open upon stretch, opening of mechanosensitive channels, or controlling membrane curvature [21].

The site, which opened in 2008, once held a pawnshop.

The PACAP specific binding sites which were not shared VIP were termed type I, while the binding sites shared with both PACAP and VIP were termed Type II.

The sequence of this binding site does not resemble any known ATP binding sites, which have much higher binding affinities.

Interestingly, channel-gating behaviour was also reported to be dependent on the nature of the substitution with a R64D mutation giving rise to a higher open probability than R64A, which Kremer et al. suggested to arise from the formation of a salt bridge across the non-annular lipid binding site which may stabilise the open state thereby mimicking the presence of an anionic lipid [25].

Among many other binding sites lost in the –673 construct were an E-box, a STAT binding site which forms a sequence model (Genomatix modelInspector) together with an ets binding site, and a Myc associated zinc finger binding site (MAZF).

Any binding site which had a p < 0.01 was annotated as a potential miRNA binding site.

The ion-binding sites, which are located within the transmembrane domain, are open toward the cytoplasm in the E1 state and toward the lumen of the SR (or extracellular side) in the E2 state.

Molecular modelling studies suggest that these compounds might bind at the peripheral binding site of AChE, which opens the possibility to design inhibitors able to bind at both, the catalytic and peripheral binding sites of the enzyme.

That site, TBD, which opened in 2010, was closed two years later.

The structures show that the dimerization induces a large-scale conformational change in plexin, which opens the GAP active site to allow Rap binding.