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Three-dimensional structures of several flaviviral MTases bound to SAH, with either GTP or cap analogues, have delineated the co-factor and one cap- binding sites which lie about 16 Å apart.
Equally, MV-H engages its CD46 and SLAM entry receptors at overlapping binding sites which lie along the outside of the β-propeller, whereas HNV-G binds to ephrinB2 and ephrinB3 at the top and centre of the β-propeller.
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However, the approaches fail for sites which lie outside the area of gauged sites.
The PACAP specific binding sites which were not shared VIP were termed type I, while the binding sites shared with both PACAP and VIP were termed Type II.
The sequence of this binding site does not resemble any known ATP binding sites, which have much higher binding affinities.
The two glycine residues affected by the SNPs lay adjacent to the FKBP12.6 binding site, which recently has been assigned to the residues 1636 1937 (21636 1937
Among many other binding sites lost in the –673 construct were an E-box, a STAT binding site which forms a sequence model (Genomatix modelInspector) together with an ets binding site, and a Myc associated zinc finger binding site (MAZF).
Any binding site which had a p < 0.01 was annotated as a potential miRNA binding site.
These regions of low variation also coincide with elements identified as functional binding sites for transcription factors, which lie within the proximal promoter (Figure 1).
Nicotine works by binding to nicotinic cholinergic receptors, which lie on the surface of many cells throughout the body and brain.
The equivalent residues in the human variants of eEF1A that have been proposed to be part of the aminoacyl-tRNA binding site [38] are Arg322, His295 and His296, which lie within domain II.
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