Your English writing platform
Discover LudwigSuggestions(5)
Exact(9)
Thus, the attachment of streptavidin to the biotin-terminated patterns leaves some biotin unoccupied binding sites, which can be used subsequently to pattern other biomolecules that are conjugated with biotin.
Computer simulations have shown that this is indeed the case for eukaryotic transcription factor binding sites, which can appear neutrally within microevolutionary timescales [13].
Second, the short-life of protein chromatin interactions continuously makes available binding sites which can then be scanned by diffusing transcription factors.
Gene duplication may aid in generating paralogous TFs with similar binding sites, which can then be selected according to the cost and benefit of their action on the target genes.
The structures show that CYPs have large, flexible binding sites, which can accommodate more than one substrate molecule, and allow for mutual influences of chemicals, which can act as substrates, activators, or inhibitors.
Analysis of the ChIP assay on human chromosomes 21 and 22 (~3% of genome) revealed 48 binding sites, which can be extrapolated to ~1,500 sites in the whole genome [ 49].
Similar(51)
The rat theta-class glutathione transferase T2-2 (rGST T2-2) presents an ideal scaffold for the design of a novel GPX catalyst because it already binds GSH and contains a serine close to the substrate binding site, which can be chemically modified to bind selenium.
AES is an enzyme-inhibiting aptamer bearing a target-molecule binding site which can allosterically control enzymatic activity.
These analogs serve as useful molecular probes to explore the secondary binding site, which can be exploited in designing more potent DAAO inhibitors.
The −1195 A→G polymorphism creates a c-MYB binding site, which can activate COX-2 expression, and displays a higher promoter activity [15].
This surface coincides with a distinct binding site, which can accommodate either Ub or the Ub-like domain of HHR23 proteins (26).
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com