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The mAbs binding sites were thereby narrowed down to one of the COMP domains.
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The identified binding sites were then scored for their enrichment compared to a randomized list of genes, thereby generating both a Z and Fisher score.
Nevertheless, differences surrounding the JAK1 and JAK2 ATP-binding sites were apparent, thereby providing a platform for the rational design of JAK2- and JAK1-specific inhibitors.
Twelve binding sites are present within the dodecameric channel.
[3H]nicotine binding sites are associated with mammalian optic nerve terminals.
These binding sites are highly charged.
Noteworthy, these binding sites are juxtaposed to GATA3-binding sites.
The selective and potent D2 receptor agonist - R -2-OH-NPA was positioned in the binding site during the construction of the receptor model and thereby induced a conformational change of the receptor, where the binding site is shaped to accommodate an agonist.
In this study random and targeted mutagenesis of the sequence upstream (−88 to −52) of the Mor binding site was performed to determine whether Pm also contains an UP element for binding of the RNAP α subunit, thereby stimulating transcription.
The left TALEN binding site is 5-TACAACAATCTCCAGAT-3 and the right TALEN binding site is 5-ATGCCACAGACGAAGGGCCCATA-3.
Thus, the underlying Ca2+ binding site is not intracellular.
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CEO of Professional Science Editing for Scientists @ prosciediting.com