Sentence examples for binding sites were restricted from inspiring English sources
The conserved anonymous motifs and transcription factor binding sites were restricted to a sequence window of ± 2 kb of the consensus transcription start site.
The conserved anonymous motifs and transcription factor binding sites were restricted to a sequence window corresponding to 2 kb up-stream and 2 kb down-stream of the transcription start site while the conserved miRNA recognition sites were restricted to the 3' untranslated region of genes.
Response: These comments seem to imply that we are claiming that the TF binding sites are restricted to pre-miR sequences and NOT also enriched in flanking regions.
The more robust phenotype of these factors is likely due to their inclusion in many different transcriptional complexes, whereas REST binding sites are restricted to a more limited set of sites in the genome.
The fact that both ORC and Fkh1/2-binding sites are restricted to the NDR suggests that the NDR is critical for accommodating functional complexes in the origins.
The conserved transcription factor binding sites and anonymous conserved motifs were restricted to a sequence window corresponding to ± 2 kb of the transcription start site while the conserved miRNA recognition sites were restricted to the 3' untranslated region of the genes in this cluster.
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Residues defining the binding sites were selected for site-directed mutagenesis.
MEME motif 4, lying to the N-terminal region of the -10 binding site, is largely restricted to PA sigma factors but is also present in 2 ECF sigma factor paralogs.
