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Consensus binding sites were preferred over physiological sites since they probably better reflect the general DNA binding properties of a given transcription factor.
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Furthermore, chicken nuclear DNA has a 42% to 43% guanine and cytosine base-pair content [35] which is acted upon by cisplatin, where guanine bases (especially the N7 sites) are preferred sites for Pt binding to DNA [36].
Further, hydrogen adsorbs at all oxygen sites where binding is strongest at the bridge sites on the V2O5 010) surface whereas on MoO3 010) the terminal sites are preferred.
Therefore, integrations into transcriptional active chromatin sites are preferred.
Residues defining the binding sites were selected for site-directed mutagenesis.
When large numbers of binding sites are already known, this formalism should be preferred to PWMs in predicting new sites.
Since the ligand chemistry of these binding sites is specifically tuned to prefer Zn2+ over other transition metal ions [ 211, 212], it is equally unlikely that they served first to bind some other metal, e.g. iron, and only later adapted to binding zinc.
Remarkably, despite these differences, their kinetically preferred binding sites are identical within the SRL.
Twelve binding sites are present within the dodecameric channel.
[3H]nicotine binding sites are associated with mammalian optic nerve terminals.
These binding sites are highly charged.
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