Sentence examples for binding sites were enriched from inspiring English sources
Dozens of consensus sequence motifs containing predicted transcription factor binding sites were enriched in genomic regions with regeneration-responsive H3.3 occupancy.
Many transcription factor binding sites were enriched, including motifs binding the oncoprotein MYC (Table S3).
Therefore, we sought TFs downstream from EGF whose binding sites were enriched in promoters of upregulated tumor genes.
Several transcription factor binding sites were enriched in these differentially regulated target genes, including CCAAT-displacement protein (CDP).
HLH-1 binding sites were enriched upstream of genes known to be expressed in muscle, consistent with its role as a direct transcriptional regulator.
Given transcription factors whose binding sites were enriched in transgenic or tumor gene sets, we sought upstream regulators of these TFs that may contribute to their activation or inhibition through signal transduction pathways.
This analysis selects transcription factors whose binding sites are enriched in ChIP-enriched regions compared to background promoters (see Methods).
Thus, Insm1, Neurod1 and Foxa2 frequently bind in close proximity in chromatin of pancreatic β-cells, and high affinity binding sites are enriched in sites co-occupied by all three factors.
Analysis of off-target binding sites showed the importance of the PAM-proximal region of the sgRNA guiding sequence and that dCas9 binding sites are enriched in open chromatin regions.
Nucleosome positioning at distinct subsets of promoters additionally requires the essential Myb family proteins Abf1 and Reb1, whose binding sites are enriched in NFRs.
Third, transcription factor binding sites are enriched amongst the top association results pointing towards disturbed regulatory network function in asthma.The next wave of asthma genetic studies will use full-genome sequencing and overcome most GWAS-associated problems.
