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In this case, to make a fair comparison, only the residues located up to 5 Å from the ligands (i.e. those lining the BEN/ATP/PLP binding sites) were considered.
Two binding sites were considered distinct if their seed region loci in the multiply aligned 3'UTR sequences were different.
The analysis was performed for all vertebrate transcription factor matrices in the 2009.1 release of TRANSFAC [50], and putative binding sites were considered to be evolutionarily conserved if matches were also found at the aligned positions in both chicken and frog sequences and had no gaps present in the multiple alignment of these species.
Top 7000 binding sites were considered in each condition.
Strong non-conserved binding sites were considered true positives if they were identified upstream of genes that are functionally related to known members of the regulon.
In this study not only specific NF-κB binding sites were considered but also the binding sites for p50, p65 and cRel, which show clustering of TFBS among Early genes.
Similar(51)
Carbohydrate binding sites are considered important for cellular recognition and adhesion and are important targets for drug design.
In order to explain the different activities between the AChE and BuChE, the ligand binding sites are considered in both enzymes, such as active site and peripheral anionic site (PAS).
When only putative recombinase binding sites are considered, FL-CS-2798 and FL-CS8-2798 difrom from FL-2798 by five and eight nucleotides, respectively.
Based on this and the Virtual Cell simulations with a mobile genome, a second model with two discrete binding sites was considered.
Divergence of transcription factor binding sites is considered to be an important source of regulatory evolution.
More suggestions(21)
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binding steroids were considered
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binding motifs were considered
binding mechanisms were considered
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binding interactions were considered
binding sites were required
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binding sites were used
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