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Putative σ54 binding sites were associated with 121 candidate loci (Table S4), including several previously unannotated homologues of Qrr loci [58] in Vibrio sp. LexA is a global regulator of the SOS response.
Only about 30% of the EIN3 binding sites were associated with transcriptional changes, but at least two-thirds were not.
In total, 285 (4%) CREB binding sites were associated with fasting-induced genes, and therefore considered to be the most likely cAMP-responsive sites in liver.
As transcription factor binding to a gene does not necessitate transcriptional regulation, we performed microarray analysis to determine which of the identified p63 binding sites were associated with transcriptional regulation of nearby genes.
For example, the sentence "many EIN3 targets were not transcriptionally ethylene-regulated (EIN3-NR) (67%), while a subset of the EIN3 targets was transcriptionally ethylene-regulated" should be rephrased as "only about 30% of EIN3 binding sites were associated with transcriptional changes; at least two third were not".
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Both ligand binding sites are associated with the functionally important PrgI self-oligomerization sites.
Genome-wide tiling arrays demonstrate that ER binding sites are associated with different transcription factors that are important for gene activation [48], [49], [50].
Intriguingly, genes containing AP2-Sp binding sites are associated with a wide range of biological processes, such as sporozoite formation, host cell invasion or liver stage development.
It was further noted that multiple Hap complex binding sites are associated with induction (Fig. 3A).
Hence, methylation of CpGs located within both gene bodies and transcription factor binding sites is associated with increased gene expression.
Albeit transcription factor binding sites are associated with promoters of several PcG target genes the establishment of epigenetic patterns can hardly be explained by this overlap alone.
More suggestions(15)
binding sites were compared
binding sites were identified
binding regions were associated
binding sites was associated
binding proteins were associated
binding sites were isolated
binding sites were examined
binding sites were implicated
binding sites were required
binding sites were blocked
binding sites were studied
binding sites were used
binding sites were aggregated
binding sites were enriched
binding sites were mutated
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