The N-terminal binding site is additionally dependent on membrane curvature, the fragment binding less efficiently to more highly curved membranes (Supplementary Figure S4).
Additionally, AR binding sites were enriched with sequence motifs recognized by the ABDB (Abdominal-B type homeodomain transcription factors) family (Additional file 3: Table S3), suggesting potential combinatorial control between androgen receptor and homeobox genes.
Additionally, when the binding sites were preoccupied with free testosterone, the number of binding events dropped down to 67 from 183 detected interactions in the case of sbAvd-1.
Additionally, the properties of binding sites were studied for mRNA sequences of both human and other animal species.
Additionally, new p53-occupied binding sites were identified for the MDM4 and dyrk3 genes, for which different p53 binding locations have previously been described [ 5].
Additionally, Sp1 binding sites are found in the promoters of many housekeeping genes (Black and Azizkhan-Clifford, 1999).
Additionally, some binding sites are present in the nucleotide sequences but are not involved in the regulation of genes in certain conditions by being inactive [ 23].
Additionally, we confirm that newly identified low-affinity enhancer binding sites are functional in vivo, and that their contribution to gene expression matches their predicted affinity.
Additionally, important sequence features, such as interactions among adjacent binding sites, are often not represented in these approaches.
Nucleosome positioning at distinct subsets of promoters additionally requires the essential Myb family proteins Abf1 and Reb1, whose binding sites are enriched in NFRs.
