Sentence examples for binding sites we showed from inspiring English sources

By mutating either or both of these binding sites, we showed using the reporter assay that each site is required for full promoter activity.

Using an operational definition of functional binding sites, we showed that for a large number of TFs, functional binding is location sensitive.

Using a radiolabeled oligonucleotide probe corresponding to this putative p63 binding site, we showed specific DNA-protein complexes with nuclear extracts from HaCaT cells, an immortalized human keratinocyte cell line which has been shown to express high levels of ΔNp63 (Figure 3, lane 1).

Before reporting and discussing evolutionary hypotheses based on predicted transcription factor binding sites, we would like to show that these predictions are not random, despite the high rate of incorrect predictions.

As expected, most of the mammalian orthologs of these introns contain HNRNPH-like binding sites; however, we show that these sites are often absent in nonmammalian orthologs.

Using an Sp1 binding site mutation construct we showed that mdm2 repression did not absolutely require Sp1 binding sites in the hTR promoter, suggesting the possibility of pRB/Sp1 independent mechanisms of repression.

We then analyzed the function of converted binding sites, and showed that they are enriched for known SP1 function.

In addition, DR4 and GLI binding sites also showed significant enrichment.

The mutation of individual binding sites showed no effect on PTB binding (data not shown, Fig 4a and b).

We map ORC1/CDC6 binding sites and show that they localize to the boundaries of the transcribed DGCs in the chromosome cores.

As shown in Figure  2B, TFII-I binding sites showed a strikingly high enrichment to unmethylated CpGs, while still displaying the bifurcated distribution.