Sentence examples for binding sites we over-expressed from inspiring English sources

To investigate whether these are functional Egr-1 binding sites, we over-expressed a constitutively active Egr-1 (Egr-1*) and tested whether it could transactivate Rad promoter.

As the transcription unit evaluated in this study has 96 activator binding sites, we compared activation dynamics in cells expressing the VP16-activator to a weaker p53-activator.

To identify over-represented transcription factor binding sites, we used the Molecular Signatures Database, part of the Gene Set Enrichment Analysis software (Subramanian et al., 2005).

While we expected that over-expression of an FFRP would reveal the most comprehensive set of binding sites, we also expected that only a subset of these binding sites would be conditionally functional in any given environment.

To identify native TR-binding sites, we prepared chromatin from the TRα1 expressing tissues brain and heart of TRα1 GFP mice, and performed ChIP with an anti-GFP antibody.

RNA Pol II binding sites were prominent over highly expressed genes with a peak of greatest density right around the TSS.

We used the program Sylamer to identify the representation of 3'UTR miRNA binding sites in genes over or under expressed in a given cell type [ 18].

For the correlation between tissues dependent on the number of binding sites for expressed miRNAs, we randomly permuted the number of binding sites between the miRNA and the mRNA pairs.

In order to search for potential new therapeutic targets, we relied on computational methods aimed at identifying transcription factor binding sites (TFBSs) over-represented in the promoter regions of genes differentially expressed in PAC.

We also identified miRNAs whose binding sites are over-represented in eIF4E upregulated mRNAs (Table 6).

We show that membrane testosterone binding sites are preferentially expressed in prostate carcinoma cells, while BPH and non-malignant epithelial cells show a low or absent binding.