Sentence examples for binding sites we observed from inspiring English sources

However, it is interesting to mention that when computing the ratio between the total number of predictions along different conservation levels and the number of successfully identified ChIP-seq binding sites, we observed better predictive values for higher sequence conservation (see Additional file 8, bottom).

The enrichment of NF-Y binding sites we observed in the promoters of genes encoding proteins that peak in the G2&M fraction is consistent with previous reports linking NF-Y transcriptional activity to G2&M phase cell cycle functions (Hu et al., 2006).

Upon either deletion or mutation of the BP1 binding site, we observed an approximately 40%to50%0% decrease in bcl-2 promoter activity.

This region of the ribosome is known to play a role in the initiation of translation, and thus, the binding site we observe is consistent with evidence suggesting that thermorubin inhibits the initiation stage of protein synthesis.

Due to the nature of these families, their size is significantly larger than of those of the simple protein target families representing one binding site; we observe this to be a big influence on the results.

This extensive analysis revealed that the majority of PPARγ binding sites we mapped overlap with those previously reported although some differences in specific binding sites were observed, likely due to inherent differences between 3T3-L1 and C3H10T1/2 cells.

Further studies are required to determine if the binding site specificity we observed is an intrinsic property of HLH-1 or reflects additional constraints, including required cooperativity with other factors or the limited accessibility to potential binding sites in the context of general or tissue-specific chromatin organization.

Finally, using methylation dependent immunoprecipitation (MeDIP), we also determine the overall methylation status of MYCN binding sites and observed a striking correlation between MYCN binding and DNA hypermethylation status in the neuroblastoma cell lines studied.

Two potential polyphosphatidylinositide binding sites are observed, one on α and one on μ2.

According to the Langmuir isotherm model, a heterogeneous distribution of binding sites was observed in the polymers.

As described above, the incorporation of fpocket cavity detection into BSC introduces the potential for noise in the binding site dataset compared to only defining binding sites surrounding observed bound ligands, and this may result in poorer retrieval performance metrics.