Sentence examples for binding sites we have from inspiring English sources
The perfect complementarity between the mir122 binding sites we have inserted and microRNA mir122 should result in substantial E1A mRNA cleavage through a mechanism similar to RNAi.
To reduce the possibility of generating of de novo TF binding sites we have used the SeqenceShaper program (http://www.genomatix.de).de
As, indeed, we cannot offer much more than speculations on the functional implication of these binding sites, we have moved Figure 4G to the supplementary information.
To address the specificity of NBS1 and NBS4 core binding sites we have introduced transversion point mutations to the core cognate elements aiming to disrupt the NKX3.1 homeodomain DNA recognition.
However, due to a very high CG content (80 90%) of the CpG island in the close proximity of Egr2 binding sites, we have not succeeded to discern the individual Egr2 motifs in order to generate their individual mutants by PCR-based mutagenesis.
Since mutagenesis studies have identified drug binding sites, we had a closer look at phalloidin binding sites.
Although previously defined genomic sites contain multiple TAAT sequences with flanking bases distinct from those in the optimal binding site, we have found a new binding site with seven near-perfect repeats of the optimal sequence; this site is located in the promoter region of decapentaplegic, a probable Ubx regulatory target.
Utilizing previous SAR and analysis of the amino acid sequences in the binding site we have designed inhibitors displaying increased PKA and general kinase selectivity with improved tolerability compared to the progenitor pyrrolopyrimidine (1).
To localize the binding site, we have also performed J-surface mapping using the same perturbation data.
To validate the drug targetability of our proposed binding site, we have repositioned some of the most promising in vitro, in vivo validated anti-herpes molecules onto the proposed binding site of gH-gL complex in a computational approach.
Since the physiological role of these regulators is critically dependent upon effector binding and operator sites, we have analysed and classified these regulators into their specific subfamilies and identified their potential binding sites.
