Sentence examples for binding sites we designed from inspiring English sources

Based on the global chip array results with potential SALL4 binding sites, we designed 3 sets of primers for the ABCA3 promoter region (one was from a peak region, two sets were designed on non-peak regions for negative controls) and two sets of primers for the ABCG2 promoter regions (Figure 4A).

Starting from the available information about the binding of the purine-based htIIα inhibitors in the ATP binding site we designed a virtual screening campaign combining structure-based and ligand-based pharmacophores with a molecular docking calculation searching for compounds that would contain a monocycle mimetic of the purine moiety.

To identify a binding site, we designed a series of oligonucleotides covering the entire region between bcg1280c and the first 10 nucleotides of raaS (Fig. 3B) and performed electrophoretic mobility shift assays (Fig. 4B).

Utilizing previous SAR and analysis of the amino acid sequences in the binding site we have designed inhibitors displaying increased PKA and general kinase selectivity with improved tolerability compared to the progenitor pyrrolopyrimidine (1).

By targeting an extended region of the conventional 'DFG-out' pocket of p38α, while minimizing interactions with the specificity pocket and eliminating interactions with the adenine binding site, we are able to design and synthesize a number of pyrazole-urea based DFG-out p38α inhibitors with good potencies, and excellent selectivity.

To confirm the incorporation of metal ions at the designed metal binding site, we determined the crystal structures of mutant MB in its oxidized form at 3.1 Å resolution and mutants MA1 and MA1B in their reduced forms at 2.2 and 2.0 Å resolution, respectively.

The expression of GPPS was optimized by using ribosomal binding sites (RBSs) designed to have different translation initiation rates (TIRs).

A simple turn-on fluorescent anion chemosensor with amide moiety as binding sites was designed, synthesized and characterized.

A 1,2,3-trioctyloxyphenyl-based organogel (G1) containing a pyrene fluorophore and urea-sulfonamide anion binding sites was designed and synthesized.

A novel fluorescent chemosensor HACBA with carbazole-hemicyanine fluorophore as signal reporter and N,N,N'-tri 2-pyridylmethyl)ethyleN,N,N'-tri 2-pyridylmethylg sites was desigN,N,N'-tri 2-pyridylmethyl

Based on NN703, low molecular weight growth hormone secretagouges (GHSs) with a reduced number of hydrogen binding sites were designed by removal of the C-terminal amide group.