Sentence examples for binding sites we built from inspiring English sources
The comprehensive resource of TF binding sites we built thus provides a reference map for understanding complex gene expression patterns.
To build the initial PWM form the training set of experimentally defined binding sites, we used 63 experimentally defined motifs for human GATA-3 from Jaspar database [ 40, 48, 49].
First, we compare the use of Dmel PWMs built from the known binding sites versus phyloPWMs built from orthologous binding sites from 10 other Drosophila species.
DNase-I-hypersensitivity data for IMR-90 cells was integrated with TF binding sites to build an IMR-90-specific prior network consisting of 571 transcription factors and 4059 target genes [ 36].
The observed frequencies were calculated from the binding sites used to build the new di-nucleotide PWM.
The question whether regional centromere/kinetochores containing multiple microtubule-binding sites are built from the repetition of a simpler functional unit remains open.
In order to compare signal transduction through a Grb2-binding site with signal transduction through a ShcA-binding site, we replaced the ShcA-binding site in the NGF receptor with a Grb2-binding site.
To map the binding site of Jac-A, we built complex structure of the compound with Bcl-xL by docking.
Evidence for the existence and location of a binding site can be built through experimental observation of protein ligand binding events—often facilitated by protein X-ray crystallography and/or Nuclear Magnetic Resonance NMRR) spectroscopy.
These results suggest that VH-B1a and other autonomous VH domains may be useful scaffolds to support both conventional libraries with antigen-binding sites built from the three CDR loops and, also, nonconventional libraries with antigen-binding sites built from CDR3 and the former light chain interface.
The putative zinc binding site 3 is build by three histidines and one glutamate, but the exact biological function of this protein site remains to be determined [ 23].
