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A simple turn-on fluorescent anion chemosensor with amide moiety as binding sites was designed, synthesized and characterized.
A novel fluorescent chemosensor HACBA with carbazole-hemicyanine fluorophore as signal reporter and N,N,N'-tri 2-pyridylmethyl)ethyleN,N,N'-tri 2-pyridylmethylg sites was desigN,N,N'-tri 2-pyridylmethyl
An organogelator G1 based on multi self-assembly driving forces, fluorescent and colorimetric signal groups and anions binding sites was designed and synthesized.
A 1,2,3-trioctyloxyphenyl-based organogel (G1) containing a pyrene fluorophore and urea-sulfonamide anion binding sites was designed and synthesized.
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Based on NN703, low molecular weight growth hormone secretagouges (GHSs) with a reduced number of hydrogen binding sites were designed by removal of the C-terminal amide group.
Simple and efficient sensors 1 and 2 possessing azo and nitrophenyl as signaling units and urea and thiourea moieties as binding sites were designed and synthesized.
For several genes, multiple putative promoters were identified by the program (up to 4 for ARRDC3) and primers surrounding the putative forkhead binding sites were designed.
The binding sites were designed to allow incomplete base pairing with miR-312, such that the 5'seeded' and 3' regions of the miRNA would be fully base paired, with a central unpaired bulge (Fig. 1D).
The oligonucleotides flanking transcription start site and predicted Tcf4 binding sites were designed within ~200-bp windows in the 700-bp upstream of the transcription start site (amplicon U), and in the 500-bp windows downstream of transcription start site (amplicon D) for detecting miR-181a-2 miR-181a-2 miR-181a-2er.
To confirm the presence of a putative binding site for miR-24-2 withen the 3'UTR region of the BCL-2 gene, the specific primers flanking the binding sites were designed and the resulting amplicon was cloned into the 3'UTR region of the luciferase gene of the reporter vector pGL3 (pGL3/ BCL-2).
In this study, based on the anti-proliferative activities, a novel tubulin inhibitor 7a3 targeting the colchicine binding site was designed, synthesized, and optimized from a series of novel cis-restricted pyrazole analogues of combretastatin A-4.
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