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Saturation analysis showed that the Bmax of [3H]citalopram binding sites was also significantly lower in the pups prenatally treated with cocaine than in those prenatally treated with saline.
Considering (1) the close structural similarity with other active flavones, (2) the activity of some of its glycosilated derivatives and (3) the complexity of flavonoid effects in the central nervous system, luteolin was submitted to a battery of tests designed to evaluate its possible activity upon the CNS and its ability to interact with the BDZ-receptor binding sites was also analysed.
The competitive effect of the activators and repressors for the promoter binding sites was also simulated.
SNP density in the miRNA binding sites was also lower than that in their flanking regions.
In the goldfish, a high density of GRP binding sites was also found in the preoptic region of the hypothalamus (Himick et al., 1995).
The top motif for the 3360 Spi-B binding sites was also the Spi1 motif with an E-value of 4.1e-398.
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Moreover, three additional SNPs associated with three transcription binding sites were also identified, which might explain the differential response of Os04g27430 during the anti-feeding test.
Several clusters of binding sites are also predicted for TFs that are important for mesoderm development (Figure 6).
Highly efficient and specific displacements of both ligands from their endogenous mitochondrial binding sites were also demonstrated (data not shown).
Hence, we concluded that, similar to the Atf1, major Pcr1 promoter binding sites were also present before H2O2 treatment.
Similarly, zero binding sites is by far the most frequent case among the MAP number of binding sites (Figure 14 (b)) and the expected number of binding sites are also heavily biased towards small values (Figure 14 (c)).
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