Sentence examples for binding sites underlying the from inspiring English sources

This finding suggests that the binding sites underlying the respective activation/inhibition mechanisms are not identical.

On the contrary, no significant changes were observed in cells transfected with a PII-1.3 reporter plasmid bearing a SF-1/LRH-1-mutated binding site, underlying the importance of this motif in the regulation of aromatase expression by androgens in MCF-7 breast cancer cells.

Zinc-mediated inhibition of GABA(A) receptors: discrete binding sites underlie subtype specificity.

These sites underlie the concept of the 'epigenetic clock'.

Membrane binding and autoradiographic studies on rat brain suggest the existence of polyphenol specific plasma membrane binding sites, possibly underlying the neuroprotective action of polyphenols [21].

The results suggest that curaxin-induced partial dissociation of CTCF from its binding sites might underlie the changes in 3D genome organization observed.

As the IG-DMR was significantly broader than the ATRX-binding site, only reads underlying the ATRX peak were extracted from this region.

Further investigation is required to identify the specific topo IIα binding sites and delineate the underlying mechanisms.

There remains a need for computational approaches that can, in the absence of experimental TF binding data, leverage transcriptional data and genomic information to identify the network of TFs and binding sites that underlies a transcriptional response.

To characterize sequences underlying the binding sites, we analyzed them with the p53scan algorithm [23] and found that the vast majority of the identified p53-binding sites (86% and 88% respectively) contain a p53 consensus motif irrespective of the treatment.

Positioning of the nucleosomes on specific locations with respect to factor binding sites can control the accessibility of underlying DNA and allow the transcription machinery to work effectively in a chromatin environment [ 1].