Sentence examples for binding sites to regulate from inspiring English sources

After degradation of its cytoplasmic inhibitor IκB, the NF-κB proteins translocate into the nucleus and bind to their cognate DNA binding sites to regulate transcription of a large number of genes.

Our results are consistent with a model whereby the transcriptional regulators TTX-1 and ZTF-16 act independently through distinct binding sites to regulate ver-1 and perhaps other genes required for AMsh glia remodeling.

These experiments demonstrated that miR-875 and miR-3144 interactedirectlyly with their binding sites to regulate luciferase reporter expression, and the effect was supposed to be highly specific, as it was abolished when the target sequence was single-nucleotide or two-nucleotide mutated.

They may not act as isolated transcription factor binding sites to regulate gene expression.

Hence, in vitro studies suggest that NikR can use three distinct metal binding sites to regulate its affinity for DNA.

The limited number of target genes (158) relative to the 339 AR binding sites can be explained by the functional involvement of multiple AR binding sites to regulate the expression of a single gene, as illustrated at the KLK3 locus (Appendix Fig S8).

Different eukaryotic transcription factors can act through the same upstream binding site to differentially regulate target gene expression, but little is known of the underlying mechanisms.

Gene expression programs depend mainly on transcription factors which bind to upstream sequences by recognizing short DNA motifs called transcription factor binding sites (TFBSs) to regulate their target gene expression [ 1].

See the following: Many studies have shown that microsatellites can serve as transcription factor binding sites (TFBSs) to regulate gene expression [for a review, see [ 19]].

Many studies have shown that microsatellites can serve as transcription factor binding sites (TFBSs) to regulate gene expression [for a review, see [ 19]].

Using backbone and side chain nuclear magnetic resonance (NMR) relaxation dispersion techniques, we were able to monitor directly the conformational rearrangement process by which the KIX domain communicates information about the presence of a biological target at the MLL binding site to the allosterically regulated c-Myb/pKID binding site.