Sentence examples for binding sites to form from inspiring English sources

With the assistance of accessory proteins that induce DNA loops, Int bridges pairs of distinct arm- and core-type DNA binding sites to form synapsed recombination complexes, which then recombine via a Holliday junction (HJ) intermediate.

Thus the peptide could be loaded onto fluorochrome-conjugated streptavidin protein, which has four biotin binding sites, to form a tetrameric, fluorescent peptide-streptavidin complex.

Thus, the presence of excess cytoplasmic huDysGFP likely displaces some of the endogenous Dystrophin, rather than forcing extra binding sites to form.

However, according to our computational analysis, the sequence variants all retain the ability of the Sp1 binding sites to form G-quadruplex structure.

DOI: http://dx.doi.org/10.7554/eLife.04236.013 A cornerstone of mechanisms regulating transcription is the productive encounter of one or more TFs with their cognate binding sites to form specific protein:DNA complexes that controls the transcriptional output of a gene.

Among them, C6 protein interacts with C5b through a metastable binding site to form a soluble C5b-6 diner in the vicinity of the activating cell.

Mechanistically, MLN4924 inhibits NAE activity by binding to NAE at its active site to form a covalent Nedd8-MLN4924 adducthatat cannot move forward to subsequent intraenzyme reactions.

It was proposed that these modifications of the C-terminal regulatory domain of p53 induce an allosteric conformational change that switches the core domain from a latent form with low affinity for its DNA binding site to an active form with higher affinity for DNA [9], [14], [15].

We sampled the conformational transition from the δ-OR inactive crystal structure, in the presence of sodium at the allosteric site and the δ-OR-selective agonist SNC-80 at the orthosteric ligand binding site, to an active-like form using the G-protein-bound active crystal structure of B2AR as a target structure with ABMD (see Materials and Methods for details).

The model also includes cis-binding sites to which proteins may bind to form activators or repressors.

One of these effectors, Tir, transverses the host cell membrane and forms a binding site to the bacterial adhesin intimin.