Sentence examples for binding sites that mediate from inspiring English sources

The purpose of this study was to investigate, in human skin, the possible existence of specific binding sites that mediate the protective action of resveratrol.

However, the specific binding sites that mediate and define these regulatory connections are themselves often subject to rapid turnover.

Here we identify the putative transcription factor binding sites that mediate activity of these regulatory regions and use the information to study the regulation of the human APP locus.

A PtdIns 3,4,5) P3-induced structural rearrangement may also be instrumental for exposing, or occluding, potential JP2 protein binding sites that mediate transient interactions with other molecular components within the dyadic cleft and thus allow JP2 to act as an indirect regulator of Ca2+ cycling.

A C-terminus ubiquitin binding CUE domain identified by Shih et al. [2] as a ubiquitin binding site that mediates intramolecular monoubiquitylation.

Ultra-low-dose NLX co-treatment suppresses opioid tolerance and dependence by preventing these MOR signaling alterations [5], and we recently identified the NLX binding site that mediates its protective effects as a pentapeptide segment in c-terminal FLNA [9].

EEA1 does not contain any identifiable UIMs, but it might have a cryptic ubiquitin binding site that mediates its own ubiquitination.

The C2 domain comprises a C-terminal EFYA motif that is common to all syndecans and constitutes a PDZ domain-binding site that mediates protein protein interactions with a number of binding partners.

TG2 can act either by direct cross-linking or by its GTP-binding site that mediates signal transduction via phospholipase C, focal adhesion kinase and PI3K activation (Mehta et al. 2010).

Since the underlying cause of this induction is proposed to be linked to a transcriptional mechanism [13] [17], we cloned a proximal sequence of the PGC-1α promoter and analyzed this fragment with stringent computer-assisted analyses to identify candidate transcription factor binding sites that could mediate the AICAR effect.

The promoter region of human OPG contains various putative transcription factor binding sites that may mediate the stimulation of OPG expression by different calciotropic factors [ 7].