This fusion protein binds GAL4 binding sites that are placed upstream of an adenovirus E4 TATA minimal promoter.
Genes that show unusually well conserved potential to bind Leu3 typically have binding sites that are themselves orthologous.
This tetrapeptide binds XIAP (Wu et al, 2000) and competes with the same binding sites that are responsible for the interaction with caspases (Liu et al, 2000).
We find that human and chimp FOXP2 have similar binding sites that are distinct from previously suggested consensus binding sites.
Nucleosome-depleted open chromatin regions (OCRs) often harbor transcription factor (TF) binding sites that are associated with active DNA regulatory elements.
Sigma receptors are nonopiate and nonphencyclidine binding sites that are thought to be neuroprotective due to modulation of N-methyl-d-aspartate (NMDA) receptors.
This may suggest a rationale and guidelines for designing inhibitors that can better fit the ensemble of binding sites that are dynamically accessible to the protease.
This mechanism is not effective in the case of flexible protein binding sites that are able to deform structurally or to adapt to a bound ion.
The device, which would incorporate a nanoscale computer and several binding sites that are shaped to fit specific molecules, would circulate freely throughout the body, periodically sampling its environment by determining whether its binding sites were occupied.
ChIP-seq studies show a high concordance of functional NOTCH1 and NOTCH3 genomic binding sites that are enriched in binding motifs for RBPJ, the transcription factor that recruits activated Notch to DNA.
This should be the case for binding sites that are predominantly non-polar.
