Sentence examples similar to binding sites specified by from inspiring English sources

Using the PthXo1 TALE scaffold to optimize the Tev-mTALEN architecture, we found that choice of the N-terminal fusion point on the TALE greatly influenced activity in yeast-based assays, and that the length of the linker used affected the optimal spacing of the TALE binding site from the I-TevI cleavage site, specified by the motif 5′-CNNNG-3′.

Function is based on events taking place following binding, that is, whether the binding leads to specific subsequent binding events as specified by the cellular program.

Therefore, F-MATC Hadopts the strategy of iterating over score thresholds to optimize the overrepresentation of predicted binding sites for each specified PWM.

A perennial question is, How are the binding sites of TFs specified in vivo (Kodadek 1993)? Figure 8 illustrates several mechanisms.

All the specified targets contain miR-34c binding sites predicted by at least three target prediction programs (Miranda (Enright et al, 2003), miRtarget2 (Wang and El Naqa, 2008), Pictar (Krek et al, 2005), Pita (Kertesz et al, 2007), RNAhybrid (Rehmsmeier et al, 2004), and TargetScan (Lewis et al, 2005)).

The NPC is composed of more than 50 proteins that make up the ∼125 MDa structure [24], and the central pore is lined by FG-repeat containing binding sites contributed by multiple proteins, collectively known as nucleoporins (Nup), which are believed to be responsible for mediating and specifying transport [25].

Bioinformatic analysis of upstream regulatory regions identified conserved combinations (modules) of putative transcription factor binding sites shared by genes expressed in the same trophoblast subtype, supporting the notion that local regulatory elements, rather than locus control regions, specify subtype-specific expression.

The ligand may interconvert within a continuous ensemble of conformations specified by their binding site length l.

Binding affinities are based on structural complementarity between proteins and binding sites, with molecular binding sites modeled by bit-strings.

For GOLD (version 5.1) docking, residues of the binding site were defined by specifying the crystal structure ligand coordinates and using a cutoff radius of 10 Å, with the 'detect cavity' option enabled.

The PAX2 and MEIS1 binding sites overlap by one nucleotide.