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We finally introduced a highly conserved region within ActA sequence that possess several antibody binding sites specific to L. monocytogenes.
Antiseizure medications can be packaged in liposomal or microsomal delivery vehicles, which can be designed to couple to binding sites specific to neuronal tissue – or even, in theory, to a seizure focus.
Grouping these genes creates an increase in the abundance of binding sites specific to that transcription factor [ 31].
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Knowing that the α-subunit of AMPK can directly interact with both ERs, we wanted to determine the specific domain of AMPKα that harbours the binding site specific to ERα or ERβ or both.
As many FCI-HD TFs have mutually exclusive expression patterns (Tixier et al., 2010), a DNA binding site specific to, for example, Slou, Msh and Lb will be used by each TF in the cells in which they are differentially expressed.
The advantage of such residue independent methods is that they are not binding site specific.
Finally, a binding site-specific alignment was performed using residues within 5 Å of bound abacavir.
One of the metal-binding sites is specific to the S-turn of the A730 loop of SLVI, whereas the other four are commonly found in other RNAs.
The new metal-binding site is specific to Mn2+ and is not occupied in ternary cocrystal structures with either Mg2+ or Ca2+.
Thus, whereas MotEvo is in principle able to detect binding sites that are specific to a single species, higher probability will be assigned to those sites that exhibit evidence of selection acting to preserve them.
They are based on two principles: (1) identification of potential miR binding sites according to specific base-pairing rules in the seed region, and (2) implementation of cross-species conservation [ 17].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com