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The location of this SNP adjacent to a novel exon B and in putative HSF2 and SRp binding sites should provide impetus for downstream functional assays and additional independent validation studies to assess the role of KLK15 regulatory SNPs and KLK15 isoforms with alternative intracellular functional roles in ovarian cancer survival.
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Molecules designed to occupy the UDP-Ara4N binding site should provide specificity for bacterial targets.
These predicted sites should provide a more comprehensive list of binding sites, and regulated genes, for each PWM, but will likely also include some false predictions.
Hence the binding of ion to the M2 site should provide sufficient energy to initiate the rotation.
Sterical demand close to the phosphate binding sites should inhibit coordination to the nucleobases.
Adenine, with its two metal binding sites, should show the best affinity, whereas thymine, with no strong metal binding sites, should show little or no affinity.
Acknowledging that similar binding sites should recognize similar ligands, a structure-based alternative to docking, is the 3-D comparison of protein-ligand binding sites [37].
Intuitively, constitutive binding sites should be biologically functional.
These binding sites should not be dismissed, but rather should be the focus of additional studies.
However, defining all functional binding sites within an identified promoter is difficult, and the existence of some additional binding sites should be assumed [ 2].
Its binding site should be well characterized.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com