Sentence examples for binding sites separated by from inspiring English sources

The active nuclease is a dimer, requiring that the DNA target site contain two zinc finger binding sites separated by a short spacer.

The known Smad2/3 target genes Nodal, Lefty2 and Pitx2 contain pairs of FoxH1 binding sites separated by 30 200 bps [33], [42], [13], [43] these were termed asymmetric elements (ASEs) as they drive Nodal-dependent asymmetric gene expression.

Despite this, several highly specific promoter modules containing three transcription factor binding sites separated by a specific distance with a specific strand orientation were found in ERα target genes differentially regulated by cAMP.

The MMP-1 promoter contains at least two proximal AP-1 binding sites, separated by less than 100 nucleotides.

The hin enhancer contains two Fis dimer binding sites separated by 47 bp between their centers (Johnson and Simon, 1985; Bruist et al., 1987; Johnson et al., 1987).

We focussed on pairs of cohesin/CTCF binding sites (separated by 100 200 Kb) and computed the mean Hi-C contact intensity between all 2 Kb genomic bins located up to 40 Kb upstream and downstream of each binding site.

QRE is a bipartite binding site separated by less than 20 base pairs.

In the Workman experiment, the Gal4 binding site, separated by ∼20 bp from the nucleosome, was used to recruit SWI/SNF via a bound Gal4-VP16.

Both α-actinin and filamin have two actin-binding sites separated by a relatively flexible molecular arm.

Despite a relatively similar molecular architecture two actin-binding sites separated by a long flexible molecular arm– and similar affinity for F-actin crosslinking/bundling proteins filamin and α-actinin modulate the mechanical properties of F-actin networks differently.

DOI: http://dx.doi.org/10.7554/eLife.06249.017 10.7554/eLiFigure4 figureigure 4—figure supplement 2. Nucleosome remodeling by SWI/SNF on a template with the Gal4 binding site separated from the 601NPE by 24 bp.